Introduction of Copper Tripeptide-1 (GHK-Cu)

Copper Tripeptide-1, chemically known as GHK-Cu, is a stable chelate formed by a tripeptide composed of Glycine (Gly), Histidine (His), Lysine (Lys) and divalent copper ions (Cu²⁺). As a high-activity biochemical raw material, it is widely used in cosmetics, pharmaceutical intermediates, biological repair and other fields due to its excellent biocompatibility, targeting and multi-effectiveness, and is one of the core products with great development potential in the current high-end chemical raw material market.

I.Core Basic Information (Chemical Grade Standard)

Item	Specification Parameters	Remarks
Chinese Name	Copper Tripeptide-1, GHK-Cu, Copper Peptide	Common chemical common names, unified industry designation
English Name	Copper Tripeptide-1, GHK-Cu, Prezatide copper	INCI Name: Copper Tripeptide-1
CAS No.	89030-95-5	Unique identification number for chemical raw materials
Molecular Formula/Molecular Weight	C₁₄H₂₂CuN₆O₄ / 401.91	Accurate chemical structure parameters
Appearance	Pale blue to blue powder or crystal, odorless	Uniform color, no visible impurities
Purity Standard	≥99% (HPLC detection)	Strong batch-to-batch stability, in line with chemical grade raw material standards
Solubility	Easily soluble in water, normal saline and buffer solution, soluble in dimethyl sulfoxide (DMSO), slightly soluble in organic solvents such as ethanol and ether	Optimal solubility at pH 5.5-7.5, suitable for most formula systems
Isoelectric Point	7.3 (predicted value)	Suitable for neutral to weakly alkaline formulas
Heavy Metal Content	≤10ppm	In line with international safety standards for chemical raw materials

II.Chemical Structure and Core Characteristics

1.Chemical Structure

The core structure of Copper Tripeptide-1 is a five-membered chelate ring formed by the tripeptide GHK (Glycine-Histidine-Lysine) and divalent copper ions. The imidazole ring of histidine and the amino group of lysine form stable coordination bonds with copper ions. This unique structure can not only maintain the biological activity of copper ions, prevent oxidative damage caused by their dissociation, but also improve the skin penetration and biocompatibility of the molecule, ensuring that it stably exerts its efficacy in the application system.

2.Core Chemical Characteristics

• Strong Stability: Excellent stability in the pH range of 5.0-7.0. Avoid mixing with strong acidic components to prevent copper ion dissociation. It is suitable for most chemical formula systems and not easy to degrade.
• Good Biocompatibility: Naturally present in human plasma and saliva, non-irritating, non-toxic, with strong affinity for human cells, and can be widely used in chemical products that come into contact with the human body.
• Long-lasting Activity: It can maintain activity for a long time when sealed and stored in powder form, and can also maintain stable efficacy after reasonable treatment in solution form, which is convenient for storage, transportation and subsequent processing.
• Good Compatibility: It can synergize with various chemical raw materials such as hyaluronic acid, ceramide and vitamins, without antagonistic reaction, and can significantly improve the overall efficacy of the formula.

III. Mechanism of Action and Application Fields

1.Core Mechanism of Action

As a natural regulator of multiple cellular pathways in skin regeneration, Copper Tripeptide-1 exerts its effects through multiple mechanisms: first, it activates fibroblasts, promotes the synthesis of type I, type III collagen, elastin and glycosaminoglycans, regulates the balance between matrix metalloproteinases and their inhibitors, and realizes skin tissue remodeling; second, it reduces the expression of pro-inflammatory cytokines, scavenges free radicals, activates superoxide dismutase activity, and exerts anti-inflammatory and antioxidant effects; third, as a chemokine, it attracts immune cells and endothelial cells, promotes angiogenesis, and accelerates the repair of damaged tissues; fourth, it stimulates the proliferation of hair follicle stem cells, prolongs the anagen phase of hair, and improves the scalp microenvironment.

2.Main Application Fields (Chemical Grade Uses)

• Cosmetic Raw Materials: As a high-end active ingredient, it is widely used in anti-aging creams, repair serums, masks, eye creams and other products. The recommended addition amount is 0.05%-0.5%, which can achieve anti-wrinkle, firming, repairing, brightening and other effects. Its anti-aging effect is better than vitamin C and retinoic acid, and it is mild and non-irritating, suitable for sensitive skin formulas.
• Pharmaceutical Intermediates: Used in the synthesis of tissue repair drugs, it can accelerate the healing of chronic wounds, burns, postoperative wounds, reduce scar formation, and can also be used as an auxiliary for the repair of skin damage after radiotherapy.
• Hair Care Raw Materials: Used in hair growth products, it can stimulate hair follicle regeneration, increase hair density, and assist in improving androgenetic alopecia and alopecia areata. Its hair growth promotion efficiency is comparable to 5% minoxidil.
• Biological Repair Materials: Used in chemical products related to skin tissue engineering, it assists in the regeneration of skin epithelial tissue, repairs damaged skin barrier, and is suitable for scenarios such as post-medical beauty repair.

IV. Product Advantages

• High Purity Control: Adopting advanced peptide synthesis technology, strictly following chemical raw material production standards, each batch of products is tested by HPLC, with purity ≥98%, no harmful impurities, small batch-to-batch difference, ensuring stable product efficacy.
• Customized Services: According to customer needs, we can provide products with different purities (98%-99%) and different packaging specifications (5g/bag, 10g/bag, 1kg/bottle, 5kg/cardboard drum), suitable for production needs in cosmetics, pharmaceuticals and other fields.
• Stable Supply Chain: Own production base, large-scale production, spot supply, which can ensure long-term stable supply, shorten customer production cycle and reduce procurement costs.
• Compliance Guarantee: The product meets international safety standards for chemical raw materials, provides complete test reports and qualification certificates, is legal and compliant, and can avoid patent risks (not for sale to countries and regions with patent protection).
• Technical Support: A professional technical team provides full-process technical guidance, including product dissolution, formula compatibility, storage conditions, etc., to assist customers in solving technical problems in the production process.

V. Storage and Usage Instructions

1.Storage Conditions

• Powder Form: Store sealed, protected from light and dry at 2-8℃, with a shelf life of 24 months; storage at -20℃ can be extended to 36 months. It is recommended to store under the protection of inert gas (nitrogen or argon) to avoid oxidation.
• Solution Form: It can be stably stored at 4℃ for 7 days, and can be stored at -20℃ in aliquots for 3 months. Use it as soon as possible after opening to avoid secondary pollution.

2.Usage Notes

• Dissolution Method: Dissolve directly with sterile water for injection, normal saline or PBS buffer (pH 5.5-7.5). In cosmetic formulas, it is recommended to add it in the final stage (≤45℃) to avoid high temperature damaging the chelate structure.
• Compatibility Taboos: Avoid mixing with strong acidic components and strong oxidants to prevent copper ion dissociation and affect product activity.
• Safety Tips: As a chemical raw material, wear gloves and masks during operation, avoid direct contact with skin and mucous membranes. If contact occurs accidentally, rinse thoroughly with plenty of water.

VI.Qualification and Testing

All our Copper Tripeptide-1 products have passed strict quality testing, and we can provide a full set of qualification documents such as HPLC purity test report, nuclear magnetic resonance (NMR) identification report, and heavy metal test report, which meet the relevant industry standards for cosmetic raw materials and pharmaceutical intermediates, with controllable and traceable quality.

With professional production technology, strict quality control and perfect after-sales service, we provide high-quality Copper Tripeptide-1 chemical raw materials for global customers, helping customers achieve product upgrading and innovation in the high-end chemical field.