Nicotinamide Riboside Hydrogen Tartrate (NRHT)

Chinese Name: Nicotinamide Riboside Tartrate
English Name: Nicotinamide Riboside Hydrogen Tartrate (NRHT); Nicotinamide Riboside L-Tartrate
CAS No.: 2415657-86-0
Molecular Formula: C15H20N2O11
Molecular Weight: 404.33
Product Grades: Chemical Grade, Food Grade, Pharmaceutical Grade, Research Grade (Customizable as required)
Core Features: A stable crystalline complex of NR and L-(+)-tartaric acid, with significantly enhanced thermal stability, photostability and water solubility compared to NR chloride; ultra-low hygroscopicity; L-tartaric acid is chiral-pure with no racemic impurities, suitable for high-end dietary supplements, pharmaceutical and biotechnology R&D scenarios

1.Product Overview

Nicotinamide Riboside Hydrogen Tartrate (NRHT) is a high-grade chiral crystalline salt, synthesized through the precise stoichiometric combination of Nicotinamide Riboside (NR, a high-quality Vitamin B3 derivative) and natural L-(+)-tartaric acid. As an efficient precursor of Nicotinamide Adenine Dinucleotide (NAD⁺), NRHT can quickly dissociate into highly bioavailable NR and L-tartaric acid after entering the human body—two well-studied basic molecules with complementary metabolic benefits. It effectively solves the core industry pain points of traditional NR chloride: poor stability under normal temperature conditions, strong hygroscopicity leading to caking, and unstable bioavailability. Relying on Maintain Biotech’s exclusive enzymatic synthesis and chiral crystal form control technology, our NRHT products have the core advantages of excellent purity, extremely low impurity content, green production, outstanding long-term stability and high bioavailability. They have become the preferred raw material for high-end dietary supplements, pharmaceutical intermediates, neuroprotective preparations and cutting-edge biological research fields, demonstrating the technical strength of core raw materials in high-end biochemical industry.

2.Core Product Efficacy

The core efficacy of Nicotinamide Riboside Hydrogen Tartrate (NRHT) focuses on the precise regulation of intracellular NAD⁺ levels, combining the strong NAD⁺-boosting activity of NR with the biocompatibility and metabolic auxiliary effects of L-tartaric acid. Compared with ordinary NR preparations, NRHT has stronger stability, faster absorption speed, fully verified safety and wider application scenarios, as follows:

• Efficiently Boost NAD⁺ Levels: As a high-quality NAD⁺ precursor, it can quickly penetrate the cell membrane, gently and efficiently increase the level of NAD⁺ in the body, make up for the loss of NAD⁺ caused by aging and pressure, and provide reliable support for cellular energy metabolism, DNA repair and sirtuin activation—clinical models have verified that its conversion efficiency is significantly better than that of standard NR chloride.
• Cell Protection and Anti-Aging: It is deeply involved in DNA damage repair and oxidative stress regulation, efficiently scavenges free radicals in the body, reduces lipid peroxidation, slows down the process of cellular senescence, and enhances cell vitality. The L-tartaric acid component further strengthens the antioxidant defense capacity, achieving a synergistic anti-aging effect.
• Metabolic Enhancement and Physical Fitness Improvement: It dual-regulates the biogenesis and function of mitochondria, promotes fatty acid oxidation and adenosine triphosphate (ATP) production, relieves fatigue, and improves exercise endurance. L-tartaric acid helps maintain physiological acid-base balance and optimize metabolic efficiency, making it very suitable for the R&D of sports nutrition and anti-fatigue products.
• Neuroprotective Effect: It can efficiently cross the blood-brain barrier, provide essential nutrients for nerve cells, stimulate neurotransmitter synthesis, improve cognitive function, memory and concentration, and at the same time help protect nerve cells from degenerative damage. It is an ideal raw material for brain health preparations targeting age-related cognitive decline.
• Anti-Inflammatory, Antioxidant and Excellent Safety: It inhibits the release of pro-inflammatory cytokines, enhances the body’s own antioxidant capacity, reduces tissue damage, and improves immune function. Comprehensive toxicological evaluations have confirmed that even high-dose administration has no obvious adverse reactions, no niacin flush side effects, and is suitable for long-term daily supplementation.

3.Core Process Advantages (Maintain’s Exclusive Enzymatic and Chiral Crystal Form Control Technology)

There are three main production routes for NR-based salt products. Maintain Biotech’s independently developed enzymatic synthesis combined with chiral crystal form control technology, as an industry-leading solution, has irreplaceable advantages compared with traditional methods, as follows:

(1) Traditional Chemical Synthesis Method

It is prepared by chemical condensation and salification reactions using nicotinamide, ribose derivatives and tartaric acid as raw materials, requiring the use of a large amount of organic solvents and strong acid-base catalysts. Core drawbacks: purity ≤94%, high content of toxic impurities (such as solvent residues, racemic tartrate), unstable crystal structure, large emissions of three wastes, harsh reaction conditions, high cost and poor batch consistency—completely unsuitable for high-end food, pharmaceutical and dietary supplement scenarios.

(2) Microbial Fermentation Method

NR is synthesized through microbial metabolism, and then salified with tartaric acid, which does not require the use of a large amount of organic solvents, but has obvious limitations: low product concentration, yield ≤62%, long fermentation cycle (7-10 days), poor chiral/crystal form controllability, large purity fluctuation, complex post-processing required, difficulty in industrial large-scale production, and poor long-term stability.

(3) Maintain’s Exclusive Enzymatic and Chiral Crystal Form Control Process (Recommended)

Adopting dual-enzyme one-pot biocatalysis + precise chiral crystal form control technology, using nicotinamide, purine nucleosides and natural L-(+)-tartaric acid as substrates, in a mild normal temperature and pressure full-aqueous reaction system, NRHT with a specific chiral crystal structure is synthesized by strictly controlling temperature, cooling rate, pH value and seed crystal conditions. This process has irreplaceable core advantages and supports full-dimensional customized production:

• Green and Environmentally Sustainable: No organic solvents are added throughout the process, no harmful waste is discharged, which is fully in line with the global development trend of green biocatalysis. No catalyst residues, the product can be directly applied to food, pharmaceutical and dietary supplement scenarios, complying with FDA GRAS, EU Novel Food and Halal certification requirements.
• Ultra-High Purity and Yield: The conversion rate of nicotinamide is ≥99%; after multi-stage refining and crystal form optimization, the product purity can reach up to 99.5%+; the impurity content (including heavy metals, solvents, racemates) is far lower than international pharmacopoeia standards. The overall process yield is greatly improved, significantly reducing the production cost of customers.
• Stable and Controllable Chiral Crystal Form: Through precise control of process parameters, crystalline products with excellent stability are obtained. Compared with NR chloride, its sensitivity to light, oxygen and humidity is greatly reduced, and hygroscopicity is negligible, which can effectively prevent caking and degradation during long-term storage and global transportation, ensuring stable biological activity of the product within the shelf life.
• Mild, Stable and Scalable Process: The reaction conditions are mild (25-30℃, pH 6.0-7.0), the whole process is traceable through the Laboratory Information Management System (LIMS), the batch-to-batch difference is extremely small, suitable for industrial large-scale production, and completely solves the industry pain points of unstable crystal form and inconsistent quality in traditional processes.
• High Degree of Customization: It can flexibly customize powder crystal form (β-configuration is preferred, special chiral crystal form options are available), bulk density, and particle size distribution; it can be processed into controlled-release/immediate-release pellets, and provide exclusive formula solutions to meet the personalized needs of customers in different fields.

4.Core Product Parameters

Parameter Name	Chemical Grade	Food Grade	Pharmaceutical/Research Grade
Purity (HPLC)	≥98.0%	≥99.0%	≥99.5% (Chiral purity ≥99.8%, detected by HPLC-CD)
Appearance	White to pale yellow crystalline powder, no caking	White free-flowing crystalline powder, odorless, no caking	White needle-like crystals, no visible impurities, non-hygroscopic
Powder Crystal Form	Standard β-configuration, customizable	Standard β-configuration, α/β mixed configuration optional	High-purity chiral β-configuration, special crystal form customizable
Bulk Density	0.45–0.65 g/cm³ (Customizable)	0.55–0.75 g/cm³ (Customizable)	0.60–0.80 g/cm³ (Customizable, suitable for tablet/capsule filling)
Particle Size	80–120 mesh (20–200 mesh customizable)	100–150 mesh (40–200 mesh customizable)	120–180 mesh (60–200 mesh, micronization option available)
Moisture	≤4.0%	≤2.0%	≤1.0% (Detected by Karl Fischer method)
Heavy Metals	≤10 ppm	≤5 ppm (Lead, Arsenic, Mercury, Cadmium)	≤1 ppm (Single heavy metal), compliant with ICH Q3D guidelines
Microbial Limit	Compliant with industrial chemical standards	Total aerobic bacterial count ≤1000 CFU/g, Mold and Yeast ≤100 CFU/g, No Escherichia coli	Sterile (Customizable); Pharmaceutical-grade bioburden ≤10 CFU/g
Storage Conditions	Sealed, stored at 2–8℃, protected from light and moisture	Sealed, stored at 2–8℃, protected from light and moisture	Vacuum-sealed, stored at ≤-20℃ to ensure long-term stability
Shelf Life	12 months (Sealed storage)	24 months (Sealed, refrigerated storage)	36 months (Vacuum-sealed, ultra-low temperature storage)

5.Core Application Areas

Backed by ultra-high purity, excellent stability and enhanced bioavailability, combined with the complementary advantages of NR and L-tartaric acid, Maintain Biotech’s NRHT is widely used in high-end markets, accurately matching the customized needs of different scenarios, and has obvious advantages compared with ordinary NR products:

1. Dietary Supplements and Health Products Field: As a high-quality NAD⁺ precursor, it can gently and efficiently increase the level of NAD⁺ in the body, alleviate cellular aging, improve metabolic function and brain health, has no niacin flush side effects, and is suitable for long-term daily consumption. It supports customization of crystal form, particle size, bulk density, pellet processing (controlled-release/immediate-release) and formula design, and is compatible with capsules, tablets, Sachet packaging, freeze-dried powder and liquid dosage forms. It is the core upgraded raw material for high-end anti-aging, brain health and sports nutrition products, compliant with FDA NDI and EU Novel Food notification requirements, and can be directly used for global market deployment.
2. Pharmaceutical Intermediates Field: Used in the R&D and production of coenzyme drugs (such as NAD⁺, NADP⁺) and therapeutic drugs targeting neurodegenerative diseases, metabolic syndrome and age-related chronic diseases. According to strict pharmaceutical R&D standards, it can provide customized powder crystal form, particle size, bulk density, pellets and formula solutions, and provide high-adaptability raw material support for the pharmaceutical field with the advantages of high purity, high stability and no residues, accelerating the process of new drug R&D.
3. Biological Research and Biotechnology Application Field: As a high-quality NAD⁺ precursor raw material with excellent stability, it provides reliable and stable experimental materials for cutting-edge research such as cell metabolism, aging mechanism, neuroprotection and sirtuin biology. High-purity chiral crystal products can be customized to ensure the reliability and repeatability of key scientific experiments, helping to promote research projects efficiently.
4. End-to-End Customization Services: Provide end-to-end customization solutions, including but not limited to: powder crystal form (β-configuration, α/β mixed configuration, special chiral crystal form), bulk density (0.45–0.80 g/cm³), particle size (20–200 mesh, micronization), controlled-release/immediate-release pellets, and exclusive formula development suitable for different products. We provide one-on-one technical support and integrated solutions to fully meet the diverse and personalized production needs of global customers.