In the scientific pursuit of health and longevity, NMN (β-Nicotinamide Mononucleotide) has emerged as a shining star. However, ensuring this precious molecule operates within the human body more stably, lastingly, and efficiently has remained a key focus for industry and technological innovation. As a factory dedicated to the R&D and production of advanced formulations, we proudly introduce a new-generation NMN solution: NMN products manufactured using cutting-edge sustained-release pellet technology. This represents not just an upgrade in raw materials, but a revolution in delivery technology.
- Why is Sustained-Release Pellet Technology Needed? – Addressing Three Major Pain Points of Traditional NMN
Traditional NMN powder or capsule formulations rapidly disintegrate and are absorbed in the gastrointestinal tract after ingestion, leading to a quick peak in blood NMN concentration followed by a rapid decline. This “pulse-type” pharmacokinetic profile presents several potential limitations:
Short Duration: Inability to provide 24-hour sustained support for NAD+ levels, potentially affecting long-term benefits like promoting cellular repair and energy metabolism.
Potential Waste: A single high concentration may exceed cells’ immediate utilization capacity, leading to partial NMN being metabolized before full use.
Possible Gastrointestinal Discomfort: The one-time release of a high concentration may cause mild gastrointestinal burden for some sensitive individuals.
Sustained-release pellet technology is precisely engineered to address these pain points. By precisely controlling the release rate of NMN, it achieves a “steady release,” allowing nutrients to be delivered like a “steady, gentle stream.”
2. Our Core: The Production and Manufacturing Process of Sustained-Release NMN Pellets
Our production strictly adheres to pharmaceutical-grade GMP standards, featuring precise and controllable processes, primarily consisting of the following core steps:
Step 1: Premium Raw Material Selection & Pellet Core Preparation
We use high-purity (≥99%) NMN raw material. Initially, inert and easily digestible microcrystalline cellulose spheres or sugar pellets serve as the inert pellet core, forming the “foundation” for drug loading.
Step 2: Layered Coating for Precise Drug Loading
In fluidized bed coating equipment, we mix the NMN active ingredient with specialized pharmaceutical excipients to form a uniform suspension or solution. This is then sprayed in layers, evenly coating the pellet core surface via precision nozzles. This process strictly controls temperature, air velocity, and spray rate to ensure consistent drug loading for every single pellet.
Step 3: Constructing the Sustained-Release Barrier for Controlled Release
This is the essence of sustained-release technology. Beyond the drug-loaded layer, we apply multiple layers of a functional sustained-release coating membrane. This membrane is typically composed of high-molecular-weight polymers (e.g., acrylic resins, ethylcellulose). Its thickness, porosity, and permeability are meticulously designed:
Time-Dependent Release: The coating membrane gradually erodes or swells in gastrointestinal fluids, forming channels for NMN to slowly and continuously diffuse out.
pH-Dependent Release: Designed to dissolve only in the specific pH environment of the intestines, protecting NMN through the acidic stomach environment and enabling targeted intestinal release, thereby enhancing bioavailability.
By adjusting the coating material formulation and process parameters, we can precisely set the release profile, achieving 8-12 hours or even longer sustained-release effects.
Step 4: Quality Control & Finished Product Encapsulation
The manufactured sustained-release pellets undergo multiple stringent quality inspections: including particle size analysis (ensuring uniform pellet size, typically between 0.5-1.5mm), release rate testing (verifying the sustained-release profile conforms to design in simulated gastrointestinal fluids), content uniformity, and microbial limit testing. Qualified pellets are finally filled into capsules or compressed into tablets for convenient consumption.
3. The Superior Advantages of Sustained-Release NMN Pellets
Long-Lasting & Steady: Achieves a “plateau effect” for blood NMN concentration, providing continuous, stable NAD+ supplementation, supporting round-the-clock cellular function.
Highly Efficient Utilization: Avoids “rollercoaster” concentration fluctuations, allowing cells to utilize NMN more fully and efficiently, potentially reducing the required daily dosage.
Excellent Tolerability: Gentle release reduces the metabolic stress associated with instant high concentrations, enhancing consumption comfort.
Targeted Release: Coating technology enables intestinal targeting, bypassing stomach acid to further improve stability and absorption rate.
4. Our Factory Commitment: Professionalism Builds Quality
As a professional sustained-release pellet manufacturer, we are not just producers but an extension of our partners’ R&D and manufacturing capabilities.
Core Technology Platform: We possess mature fluidized bed bottom-spray and top-spray coating process platforms, backed by extensive experience and stable, proven technology.
Customization Capability: We can customize pellet solutions based on client needs, including different release durations (e.g., 6-hour, 8-hour, 12-hour sustained-release) and various dosage specifications.
Rigorous Quality Control System: Full traceability from raw material intake to finished product shipment. A complete Certificate of Analysis (CoA) is provided for every batch.
Scale & Compliance: Operating a GMP-standard 100,000-class cleanroom, we possess stable mass-production capability from kilogram to ton scale, ensuring consistent product supply and unwavering quality.
Conclusion
Sustained-release pellet technology elevates NMN from a “fast-acting supplement” to a “long-lasting cellular energizer.” It represents the evolution of nutritional supplements towards a future of precision, controllability, and efficiency. Our factory is committed to leveraging this advanced formulation technology to help brand owners create differentiated, high-value next-generation NMN products, jointly delivering a superior health experience to consumers.